| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38052524 | Combination Therapy of Choline Alfoscerate With Ginkgo biloba Monotherapy in Age-Related Hearing Loss: Effects and Outcomes |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37476961 | ROS-related disruptions to cochlear hair cell and stria vascularis consequently leading to radiation-induced sensorineural hearing loss |
| Resveratrol | 📋 | ✍ | ⛔ | | 38369331 | A novel model of sensorineural hearing loss induced by repeated exposure to moderate noise in mice: the preventive effect of resveratrol |
| Curcumin | 📋 | ✍ | ⛔ | | 37497164 | Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE |
| Magnesium | 📋 | ✍ | ⛔ | | 36998904 | Dietary magnesium and calcium intake is associated with lower risk of hearing loss in older adults: A cross-sectional study of NHANES |
| Melatonin | 📋 | ✍ | ⛔ | | 37451174 | Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis |
| Metformin | 📋 | ✍ | ⛔ | | 38294616 | Repurposing metformin to manage idiopathic or long COVID Tinnitus: self-report adopting a pathophysiological and pharmacological approach |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38545900 | Vitamin D Deficiency as a Risk Factor of Tinnitus: An Epidemiological Study |
| Zinc | 📋 | ✍ | ⛔ | | 31364144 | The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media with effusion in children: a randomized controlled trial |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38246005 | Role of cytokines and Th17/Tregs imbalance in the pathogenesis of otitis media with effusion. Modulation of Notch1/Hes1/mTORC1/S6k1 signalling pathway underlies the protective effect of astaxanthin |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 37165582 | The chemoprotective potentials of alpha-lipoic acid against cisplatin-induced ototoxicity: A systematic review |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38141010 | 20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels |
| TUDCA | 📋 | ✍ | ⛔ | | 33631298 | Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum |
| Ginseng | 📋 | ✍ | ⛔ | | 34386797 | Effect of Korean Red Ginseng on Noise-Induced Hearing Loss |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37395319 | Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice |
| Vitamin C | 📋 | ✍ | ⛔ | | 38451201 | Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 33822307 | Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats |
| Berberine | 📋 | ✍ | ⛔ | | 37844727 | Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K/AKT pathway |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 36481814 | Protective effects of nigella sativa oil against gentamicin-induced ototoxicity in rats: A dose-ranging study |
| PQQ | 📋 | ✍ | ⛔ | | 37650462 | Protective role of pyrroloquinoline quinone against gentamicin induced cochlear hair cell ototoxicity |
| Vitamin E | 📋 | ✍ | ⛔ | | 31364144 | The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media with effusion in children: a randomized controlled trial |
| Astragalosides | 📋 | ✍ | ⛔ | | 38393014 | Effects of Astragaloside IV on Hearing, Inflammatory Factors, and Intestinal Flora in Mice Exposed to Noise |
| Cocoa | 📋 | ✍ | ⛔ | | 38001847 | Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model |
| CoQ10 | 📋 | ✍ | ⛔ | | 36577362 | Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse |
| Eugenol | 📋 | | | | 36756486 | IN VITRO AND IN SILICO ANTIBACTERIAL ACTIVITIES OF SYZGIUM AROMATICUM ESSENTIAL OIL AGAINST BACTERIA ASSOCIATED WITH OTITIS MEDIA IN CHILDREN |
| Luteolin | 📋 | ✍ | ⛔ | | 38414247 | Inhibition of Gpx4-mediated Ferroptosis Alleviates Cisplatin-Induced Hearing Loss in C57BL/6 mice |
| Medicinal Plants | 📋 | | | | 37730634 | Age-related hearing loss and its potential drug candidates: a systematic review |
| Pine Bark | 📋 | ✍ | ⛔ | | 27158843 | Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats |
| Puerarin | 📋 | ✍ | ⛔ | | 38043717 | Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload |
| Spirulina | 📋 | ✍ | ⛔ | | 29993223 | Effects of Spirulina on GABA Receptor Gene Expression in Salicylate-Induced Tinnitus |
| Allicin | 📋 | ✍ | ⛔ | | 31340214 | Allicin Protects against Cisplatin-Induced Stria Vascularis Damage: Possible Relation to Inhibition of Caspase-3 and PARP-1-AIF-Mediated Apoptotic Pathways |
| Antioxidants | 📋 | | ⛔ | | 37109564 | Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic |
| Avocado Oil | 📋 | | ⛔ | | 32235401 | Protective Mechanisms of Avocado Oil Extract Against Ototoxicity |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 26354537 | Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women |
| EGCG | 📋 | ✍ | ⛔ | | 34500358 | (-)-Epigallocatechin-3-gallate (EGCG) prevents aminoglycosides-induced ototoxicity via anti-oxidative and anti-apoptotic pathways |
| Hesperidin | 📋 | ✍ | ⛔ | | 38629504 | Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage |
| Lycopene | 📋 | ✍ | ⛔ | | 28639555 | Ginkgo biloba and Lycopene are Effective on Cisplatin Induced Ototoxicity? |
| Micronutrients | 📋 | | ⛔ | | 37730634 | Age-related hearing loss and its potential drug candidates: a systematic review |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 28837860 | Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea |
| Rutin | 📋 | ✍ | ⛔ | | 38653908 | Rutin Attenuates Gentamycin-induced Hair Cell Injury in the Zebrafish Lateral Line via Suppressing STAT1 |
| Silymarin | 📋 | ✍ | ⛔ | | 24719690 | Protective effect of silymarin on noise-induced hearing loss in Guinea pigs |
| Sulforaphane | 📋 | ✍ | ⛔ | | 34344210 | Sulforaphane attenuates cisplatin-induced hearing loss by inhibiting histone deacetylase expression |
| Vitamin A | 📋 | ✍ | ⛔ | | 20809938 | Uniform comparison of several drugs which provide protection from noise induced hearing loss |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 33362960 | Long-term administration of vitamin B12 and adenosine triphosphate for idiopathic sudden sensorineural hearing loss: a retrospective study |
| Acai Berry | 📋 | ✍ | ⛔ | | 35107519 | Supplementation with açaí (Euterpe Oleracea Martius) for the treatment of chronic tinnitus: effects on perception, anxiety levels and oxidative metabolism biomarkers |
| Aged Garlic | 📋 | ✍ | ⛔ | | 31823910 | Evaluation of Effect of Garlic Aged Extracts and Vitamin B12 on Noise-Induced Hearing Loss |
| Apigenin | 📋 | ✍ | ⛔ | | 34921675 | Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells |
| Arctigenin | 📋 | | | | 28026149 | Arctigenin protects against neuronal hearing loss by promoting neural stem cell survival and differentiation |
| Arjuna | 📋 | ✍ | ⛔ | | 22392241 | Antimicrobial activity of Terminalia arjuna Wight & Arn.: an ethnomedicinal plant against pathogens causing ear infection |
| Asiaticoside | 📋 | | | | 28024288 | Asiaticoside protects cochlear hair cells from high glucose-induced oxidative stress via suppressing AGEs/RAGE/NF-κB pathway |
| Baicalein | 📋 | ✍ | ⛔ | | 20004700 | Effect of Baicalein From Scutellaria Baicalensis on Prevention of Noise-Induced Hearing Loss |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 15871121 | Effective treatment of experimental acute otitis media by application of volatile fluids into the ear canal |
| Bee Propolis | 📋 | ✍ | ⛔ | | 20646352 | Effectiveness of a Propolis and Zinc Solution in Preventing Acute Otitis Media in Children With a History of Recurrent Acute Otitis Media |
| Beta-Cryptoxanthin | 📋 | | | | 26354537 | Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 35656452 | Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study |
| Caffeine | 📋 | ✍ | ⛔ | | 38320571 | Caffeine Ameliorates Age-Related Hearing Loss by Downregulating the Inflammatory Pathway in Mice |
| Calcium | 📋 | ✍ | ⛔ | | 36998904 | Dietary magnesium and calcium intake is associated with lower risk of hearing loss in older adults: A cross-sectional study of NHANES |
| Carvacrol | 📋 | ✍ | ⛔ | | 33554199 | Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model |
| Cat's Claw | 📋 | ✍ | ⛔ | | 21762882 | Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 35687003 | Garland chrysanthemum consumption ameliorates age-related hearing loss in C57BL/6 mouse; model system to explore hearing loss prevention foods in a short period |
| Citicoline | 📋 | ✍ | ⛔ | | 32984303 | Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage |
| Clove Essential Oil | 📋 | | ⛔ | | 36756486 | IN VITRO AND IN SILICO ANTIBACTERIAL ACTIVITIES OF SYZGIUM AROMATICUM ESSENTIAL OIL AGAINST BACTERIA ASSOCIATED WITH OTITIS MEDIA IN CHILDREN |
| Creatine | 📋 | ✍ | ⛔ | | 17359945 | Creatine and Tempol Attenuate Noise-Induced Hearing Loss |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 32850822 | Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro |
| Dihydroquercetin | 📋 | | | | 35286283 | Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells |
| Elderberry | 📋 | ✍ | ⛔ | | 31364144 | The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media with effusion in children: a randomized controlled trial |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 36367326 | Protective mechanism of ferulic acid against neomycin-induced ototoxicity in zebrafish |
| Fisetin | 📋 | ✍ | ⛔ | | 29568876 | Fisetin administration improves LPS-induced acute otitis media in mouse in vivo |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 32640539 | Otoprotective Effect of 2,3,4',5-Tetrahydroxystilbene-2- O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells |
| Folate | 📋 | ✍ | ⛔ | | 26354537 | Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women |
| Formononetin | 📋 | | | | 38192850 | Formononetin ameliorates cisplatin-induced hair cell death via activation of the PI3K/AKT-Nrf2 signaling pathway |
| Forskolin | 📋 | ✍ | ⛔ | | 29665656 | Forskolin protects against cisplatin-induced ototoxicity by inhibiting apoptosis and ROS production |
| Fucoidan | 📋 | ✍ | ⛔ | | 36834972 | Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells |
| Galangin | 📋 | | | | 26778349 | Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures |
| Garlic | 📋 | ✍ | ⛔ | | 12728112 | Naturopathic Treatment for Ear Pain in Children |
| Genistein | 📋 | ✍ | ⛔ | | 34602350 | The effect of genistein on cisplatin induced ototoxicity and oxidative stress |
| Ginkgolides | 📋 | | | | 25749575 | Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt-Nrf2-HO-1 signaling and reduction of NADPH oxidase |
| Goji Berry | 📋 | ✍ | ⛔ | | 22272115 | Lycium barbarum polysaccharides attenuate cisplatin-induced hair cell loss in rat cochlear organotypic cultures |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 29081120 | [Role of green tea polyphenols in noise-induced hearing loss] |
| Hesperetin | 📋 | | | | 27240489 | Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model |
| Icariin | 📋 | ✍ | | | 33679402 | Icariin Treatment Protects Against Gentamicin-Induced Ototoxicity via Activation of the AMPK-SIRT3 Pathway |
| L-Arginine | 📋 | ✍ | ⛔ | | 34801666 | Nitric oxide protects against cochlear hair cell damage and noise-induced hearing loss through glucose metabolic reprogramming |
| Lutein | 📋 | ✍ | ⛔ | | 33578233 | Protective effect of lutein against acrolein-induced ototoxicity in rats |
| Myricetin | 📋 | | ⛔ | | 32742596 | Effect of myricetin on the gene expressions of NOX3, TGF-β1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats |
| Naringin | 📋 | ✍ | ⛔ | | 33274582 | Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways |
| NMN | 📋 | ✍ | ⛔ | | 34089817 | Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity |
| Nobiletin | 📋 | ✍ | | | 38570541 | Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis |
| Oleuropein | 📋 | | | | 35418359 | Oleuropein Effect on Noise-Induced Hearing Loss |
| Phytosterols | 📋 | | | | 37619212 | Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging |
| Polydatin | 📋 | ✍ | | | 35991886 | Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs |
| Polyphenols | 📋 | | | | 38004094 | Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics |
| Pterostilbene | 📋 | ✍ | ⛔ | | 32722679 | Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis |
| PUFA | 📋 | | | | 34287672 | Dietary fat intake and risk of disabling hearing impairment: a prospective population-based cohort study |
| Salidroside | 📋 | | | | 30991096 | Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting apoptosis |
| Sesame Oil | 📋 | | ⛔ | | 32186941 | Sesamum indicum L. Oil and Sesamin Induce Auditory-Protective Effects Through Changes in Hearing Loss-Related Gene Expression |
| Sesamin | 📋 | ✍ | | | 32186941 | Sesamum indicum L. Oil and Sesamin Induce Auditory-Protective Effects Through Changes in Hearing Loss-Related Gene Expression |
| Sirtuin Activators | 📋 | | | | 36204138 | Potential therapeutic role of STRT1 in age- related hearing loss |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 12728112 | Naturopathic Treatment for Ear Pain in Children |
| Tanshinone | 📋 | | | | 37455113 | [Tanshinone â…¡A activates PI3K/AKT signaling pathway to inhibit the apoptosis of mice cochlear pericytes induced by high glucose] |
| Taurine | 📋 | ✍ | ⛔ | | 36577362 | Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse |
| Telmisartan | 📋 | | ⛔ | | 34884516 | Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats |
| Thymoquinone | 📋 | | ⛔ | | 34507120 | Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating Sirt1 activity and Bak1 expression |
| Trehalose | 📋 | | ⛔ | | 34971589 | Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 38073105 | Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential |
| Urolithins | 📋 | | | | 35546176 | Urolithin A attenuates auditory cell senescence by activating mitophagy |
| Vitamins | 📋 | | | | 36867331 | Association of vitamins with hearing loss, vision disorder and sleep problem in the US general population |
| Xylitol | 📋 | ✍ | ⛔ | | 38071837 | Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study |
| Yogurt | 📋 | | ⛔ | | 37195509 | Impact of Habitual Yogurt Intake in Mother-Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children's Study (JECS) |
